Multicompartment modeling of protein shedding kinetics during vascularized tumor growth

Simulation of the Protein-Shedding Kinetics of a Fully Vascularized Tumor

Circulating biomarkers are of significant interest for cancer detection and treatment personalization. However, the biophysical processes that determine how proteins are shed from cancer cells or their microenvironment, diffuse through tissue, enter blood vasculature, and persist in circulation remain poorly understood. Since approaches primarily focused on experimental evaluation are incapable...

Multicompartment urea kinetics in well-dialyzed children.

BACKGROUND We have reported catch-up growth with hemodialysis (HD) of approximately 15 hours/week. Without an equilibrated post-treatment blood urea nitrogen, the variable-volume single-pool (VVSP) model will not account for urea rebound, inflating the estimated HD dose (K(d)t/V). A two-pool model (FVDP) predicts rebound, but requires fixed compartment volumes for the equations to be solvable i...

Kinetics of protein aggregate growth and breakage during isoelectric precipitation

About Microalgae Growth Kinetics Modeling

Microalgae are a natural source of high-value compounds for the pharmaceutical and food industry, such as bioactive compounds, vitamins, pigments and fatty acids.1 In addition, in the long term, algae culture may be useful for production of clean fuels. Photosynthetic algal culture is carried out in photobioreactors that may be illuminated naturally (outdoor) or artificially (indoor). Availabil...

Analytical Solution of Multicompartment Solute Kinetics for Hemodialysis

Objective. To provide an exact solution for variable-volume multicompartment kinetic models with linear volume change, and to apply this solution to a 4-compartment diffusion-adjusted regional blood flow model for both urea and creatinine kinetics in hemodialysis. Methods. A matrix-based approach applicable to linear models encompassing any number of compartments is presented. The procedure req...